Alembic Adapalene Topical Gel 0.3% Acne Treatment 45 Gram Tube (Rx)Alembic Adapalene Topical Gel 0. 3% is a topical medication used in the treatment of acne. It works by decreasing keratinocyte cohesion and rising the flaking process to prevent the accumulation of oil and dead skin cells that cause oily skin and acne pores. Adapalene blocks the bumps and roughness of acne in multiple ways: it increases cell turnover to reduce plugged follicles, reduces excess sebum production, displays anti inflammatory properties,